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KMID : 0861020110260040187
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Korea Journal of Herbology
2011 Volume.26 No. 4 p.187 ~ p.194
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Comparative analysis on immune response of combination with Astragali Radix and Cinnamomi Cortex
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Jung Da-Young
Ha Hye-Kyung
Lee Ho-Young
Lee Nam-Hun
Shin Hyeun-Kyoo
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Abstract
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Objective: Astragali Radix (AR) and Cinnamomi Cortex (CC) are used to enhance immune response in Asian traditional medicine. Immuno-potentiation of the combination of AR and CC were evaluated on the cellular and humoral immune response using murine macrophage cell line (RAW 264.7) and OVA-immunized mice.
Methods: This study was designed to investigate the immuno-potentiative effects of AR, CC, and AR with CC on nitric oxide synthesis in RAW 264.7 cells and proliferation and production levels of Intereukin-2 (IL-2) in mouse splenocytes. In addition, we evaluated the plasma-specific antibody responses and splenocyte proliferation on ovalbumin (OVA)-immunized mice treated with herbal extracts.
Results: Combination treatment with AR and CC increased nitric oxide synthesis in RAW 264.7 cells and IL-2 level in splenocytes (p<0.001). Combination of AR and CC significantly enhanced the Concanavalin A- (Con A ; T cell mitogen) and lipopolysaccharide-(LPS ; B cell mitogen) induced splenocyte proliferation on the OVA-immunized mice. Combination of AR and CC also significantly enhanced plasma levels of OVA-specific IgG (p<0.01), IgG1 (p<0.05) and total IgM (p<0.01) compared with the OVA-immunized control group.
Conclusion: These results suggest that combination of AR and CC could be used as therapeutic profile on activation of immune response.
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KEYWORD
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Astragali Radix, Cinnamomi Cortex, immune response, synergistic effect
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